Top Rated Bookmakers for American Football Betting

🥇 Top American Football Betting Site22bet
💰 Best American Football OddsBet365
📈 Top American Football Betting Markets22bet
🎁 Best American Football Betting OffersBet365

So, you’ve decided to bet on American football? Well, congratulations, you’re in for a lot of excitement! The NFL is one of the most covered leagues on the whole globe, so there’s no shortage of sources to get your info from. Plus, the sport has come alive in other countries, too.

But what about the best betting sites for American football? What is the best NFL bookie in the game? You’ll find the answer to these (and many other) questions right below. We hope our short guide will steer you towards the sportsbook you deserve!

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American Football Betting Explained

american football field

Placing a bet on an NFL game is incredibly easy. For starters, you just have to go to one of many available American football betting sites and pick a game. Once you’ve zeroed in on just that single match-up, all you have to do is click on the market and add it to your betting slip. If the bet wins, the bookie will clear your slip, and you’re good to go. It’s that simple.

Oh, you’re completely new to this whole thing? No worries, our beginner’s guide to American football betting has all you need. Give it a quick read, and you’ll know where to start.

Recommended American Football Betting Websites

Licensed betting websites are all over the place nowadays. Sometime before, a license was the ultimate seal of approval, but things have changed drastically. Trusted bookmakers now need much more than a thumbs-up from a regulatory body. And besides, we at Nostrabet are only interested in verified bookies that have something to offer.

So, without further ado, here’s our list of the top online bookmakers for American football. All the sites you see have been thoroughly tested by our team, so you basically can’t go wrong with either choice. Good luck!

Rating: 5.0/5
  • Trusted Online Betting Website
  • Licensed by the UKGC
  • Best Sports Betting Features
  • High Odds
New Customers only. Registration required. Bet £10* & Get £30* in Free Bets. Sign up, deposit between £5* and £10* to your account and bet365 will give you three times that value in Free Bets when you place qualifying bets to the same value and they are settled. Free Bets are paid as Bet Credits. Min odds/bet and payment method exclusions apply. Returns exclude Bet Credits stake. +18 | Terms & Conditions time limits & exclusions apply. #Advertisement
Rating: 4.6/5
  • Extensive sports library
  • High odds
  • Separate apps for sports, casino, and poker
  • Fully legal and licensed
18+ | New UK players only | Min deposit req. £10 | Certain deposit methods excluded | Pace 1 sport bet (3+ selections) } Excl Horse Racing | Min stake £10 | Max stake £20 | Min odds 2/1 (3.0) for each selection | Max FreeBet £20 for football only | FreeBet valid for 7 days | FreeBet stake not returned | T&Cs apply | |
Rating: 4.9/5
  • Trusted & Secure Online Betting Site
  • Competitive Sports Betting Odds and Markets
  • Great Range of Casino Games
  • Professional Customer Support
New customers only. This offer is valid for 7 days from your new account being registered. Min Deposit: £10. Free Bet awarded: £10. 1 x £10 must be wagered at odds of 1.75+ to unlock Free Bet. Debit Card deposits only (exclusions apply). Free bet will expire 7 days after the 1st deposit. 18+. Bet The Responsible Way. Full Terms apply |

#1 22bet

22bet is one of the places where you can punt on American football. Despite not focusing on the U.S. market, this iGaming operator offers attractive betting options. The bookie 22Bet also has several features you can use while punting on American football.

22bet american football betting
  • Pros:
  • You can bet on pre-match and live American football
  • Better American football odds than those found on other iGaming platforms
  • You can utilize different features while punting on American football
  • Cons:
  • There are not as many markets for this sport compared to others

Visit 22Bet

#2 bet365

Bet365 has always been the preferred option for novice and experienced bettors alike, especially for different U.S. sports. People who want to bet on American Football at bet365 will find plenty of markets, special bonuses, and several features.

bet365 american football betting
The screenshot was done at 13:15 on 15.10.2021
  • Pros:
  • You can find bonuses for American football
  • The American football markets at bet365 can satisfy even the most niche tastes
  • You can use several features while wagering on American football
  • Cons:
  • The platform may be difficult to access in some countries

Visit Bet365

#3 Bwin

Bwin is a betting site where you can wager on American football. This iGaming company is famous for its minimalistic design and tons of markets. Once you check the American football section of Bwin, you will find markets that are not available elsewhere.

bwin american football betting
  • Pros:
  • American football fans can punt on multiple events from the NFL
  • Everyone interested in American football can use several features
  • Bwin’s odds for the American football are competitive
  • Cons:
  • Bwin does not offer any exclusive promos for American football

Visit Bwin

#4 Betway

Betway has been a part of the online sports betting industry since 2006. It has earned the reputation for being a reliable betting website. You can wager on numerous things, including American football. One of the main advantages of the operator is Betway boasts loads of markets, which are divided into different subcategories.

betway american football betting
  • Pros:
  • Numerous American football betting markets
  • Betway offers Cash Out
  • The bookie allows its customers to use different payment options
  • Cons:
  • Betway does not have American football-exclusive bonuses

Visit Betway

#5 Melbet

Melbet is one of the online bookmakers with an extensive selection of betting options. It is among the sites that are worth it if you are interested in American football. That is because Melbet offers hundreds of betting markets.

melbet american football betting
  • Pros:
  • Experienced and novice punters alike can use various markets for American football
  • Statistics that might help punters who are new to the sport
  • Different odds formats while betting on NFL matches
  • Cons:
  • No special promos for American football

Visit Melbet

What Betting Markets Are Available?

The best thing about modern American football betting websites is all the options they offer. It’s so much more than guessing who will win. Before you actually start with NFL betting, familiarize yourself with the following American football betting markets:

Moneyline betting

Basically, you’re betting on which team will win. Keep in mind that, in American Football betting, some betting sites only count the four quarters and not the OT.


With spreads, you’re also betting on which team will win, but you also get a little leeway. Instead of aiming for that W/L, you can also win if the underdog loses by a certain number of points, or you can lose if the favourites don’t prevail strongly enough.

Totals – Over/Under

Also known as ‘over/under/, this bet is a great way to win if you’re unsure about which team will prevail. You’re placing a wager on the cumulative number of points during the game.

Quarter/Half betting

Too impatient to wait for Q4 to end? Think your team is going to go on a run? If so, you can also bet on what happens in a single NFL quarter/half. Don’t take up this bet before you reach an intermediate skill level.

Winning margin

If you believe you have what it takes, you can bet on a margin the team will win the game by. This market is usually offered on bigger games, but high-profile sportsbooks offer it on most games.


Prop bets aren’t affected by wins or losses. Instead, you can put money on all sorts of wacky things like ‘which team will commit a 10-year penalty first’ or ‘what will the colour of Cam Newton’s cleats be.’


All NFL bets technically target the future, right? Well, in American Football betting, futures are bets with outcomes that will be known far into the future. Betting on the 2026 SuperBowl champions is one example.

Advantages and Disadvantages of American Football Betting

  • Pros
  • American football betting is not so complex
  • You can learn the basics of this sport easily
  • There is a lot of information about the events
  • Cons
  • There are only a few competitions from this sport

What’s so good about all these American football betting sites? Well, NFL betting is one of the simplest ways to get into sports betting as a whole. You will have no problems getting in the midst of things right away. It’s fun, suspenseful, and potentially rewarding.

But what about the downsides? Even though American football betting sites offer odds on so much more than money line bets, the overall coverage of the sport is still a bit disappointing. Only Canada, Brazil, and a few European countries have leagues worth betting on. Some days, there just won’t be any games on.

American Football Betting Tips & Things to Consider

american football game

If you want to win every once in a while, you have to go further than just the bookies’ predictions and basic stats. Even you can get ahead of oddsmakers every once in a while. That’s why you need to use these tips when playing at American football betting sites:

Study how the team plays — offensive/defensive?

If a team can fill it up but they have a weak defensive line, then you should avoid betting on them to win. The same goes for lackluster offences.

Choose teams that you know

If you aren’t familiar with the Jaguars’ offensive sets or how they respond to 3rd-quarter holes, then don’t bet on ‘em. Stick to what you know, and you’ll have a much greater chance of winning.

Select markets which you understand

No need to bet on obscure props or exotic bets right away. Take your time and only place bets that you are familiar with.

Checks news for injured players or roster changes

Staying up-to-date is very important. Follow reputable journalists and beat writers on Twitter. They’re usually the ones with the latest scoops.

Keep an eye on the home teams

When it comes to home teams, statheads rarely get the full picture. Even for the worst team in the league, a win is possible when you don’t have to travel far, when your fans are cheering you on, and when you don’t have to sleep in a hotel. It’s an intangible factor, but it still counts.

Why Should You Consider Betting on the NFL?

Betting on NFL games is just a way of maybe making money. Not only are you placing wagers on perhaps the most exciting sport on the planet, but you can also enjoy it with your friends and family. Aside from the social aspect, NFL betting is an excellent choice because the league is so extensively covered and written about. You can learn a lot in a short time and use it without too much effort.

Is It Worth it to Bet on American Football?

Absolutely. American football betting sites are proper behemoths nowadays. You can pick from hundreds of special bets, markets, and offers until you find something that fits your goals or playing style. Try it out, NFL betting is really easy and fun.


What is moneyline betting in American football?

A Moneyline bet is a bet with which you pick the winner. That’s it; no other factors or gimmicks involved.

Can I bet on props when betting on NFL games?

Yes, the NFL, and the SuperBowl in particular, are a gold mine for all kinds of special bets. If you can think of it, the bookies have already placed odds on it.

Am I breaking any laws by playing at American football betting sites?

Check with your state’s gambling regulatory body for more information. Even though sports betting is legal on a federal level, states still have the right to set their own rules.

Is betting on American football easy?

Compared to most other sports, it is. The rules aren’t that hard, and it’s easy to learn all the markets. Plus, there aren’t that many games during the NFL season, so you won’t feel overburdened.

How do American football betting odds change at sites?

Odds on a particular market change whenever something happens that might affect the probability of an outcome. Think along the lines of key players getting injured, coaching changes, new players joining the team, etc.

Kristiyan Kyulyunkov
Kristiyan KyulyunkovKristiyan Kyulyunkov specializes in bookmakers’ analyses. He has years of experience betting online and always keeps an eye on the different operators. His tasks in Nostrabet include writing, editing and publishing expert reviews.